Swiss pharmaceutical giant Novartis believes the anti-malaria drug hydroxychloroquine offers one of the best hopes to combat coronavirus and has donated 130 million doses as part of the pandemic response.
“Pre-clinical studies in animals as well as the first data from clinical studies show that hydroxychloroquine kills the coronavirus,” Novartis Chief Executive Vas Narasimhan told the SonntagsZeitung newspaperexternal link on Sunday.
Hydroxychloroquine, produced by Novartis’s Sandoz division among other companies, is also used to treat lupus and arthritis. “We are working with Swiss hospitals on possible treatment protocols for the clinical use of this drug [against Covid-19], but it is too early to say anything definitive,” added Narasimhan.
Hydroxychloroquine and a related drug, chloroquine, are currently under evaluation in clinical trials for the treatment of Covid-19.
Novartis had previously issued a pledgeexternal link to give away 130 million doses of the drug, including 50 million 200 gram doses it already has stockpiled. It has been reported that the United States has accepted 30 million doses.
“Novartis will work with stakeholders including the World Health Organization to determine the best distribution of the medicine to ensure broad access to patients most in need of this medicine globally,” the company stated on March 20.
Other Novartis drugs are also being explored as possible treatment for Covid-19 including the multiple sclerosis drug Gilenya and the cancer drug Jakavi, Narasimhan told the paper.
Other pharmaceutical firms are also working on bringing potential coronavirus medicines to patients. Among them is Roche, which has launched a clinical trial of a potential new Covid-19 drug Actemra.
The Swiss drugmaker said on March 20 it was working with the US Food and Drug Administration (FDA) and the US government to initiate a phase 3 trial to evaluate the safety of the drug used to treat cytokine release syndrome and rheumatoid arthritis, two inflammatory diseases.